AbAdapt

Input Requirements (Sequence)

• Sequences must be amino-acid sequences with no gaps(-) and no ambiguous residues(B, O, U, X, Z).
• FASTA headers are required to differentiate between different protein chains, but are otherwise ignored.
• Antibody sequences must contain 2 chains(Heavy/Light) with heavy always coming before light.
• Antigen sequences must contain less than 7 chains and fewer than 9999 residues total.

Input Requirements (Structure)

• Structures must be in PDB flat file format. mmCIF or compressed PDB files are not accepted at this time.
• Antibody structures must contain only 2 chains labeled H and L for Heavy and Light, respectively.
• Antigen structures must contain less than 7 chains and fewer than 9999 residues total.

Input Requirements (Reference PDB)

• Structures must be in PDB flat file format. mmCIF or compressed PDB files are not accepted at this time.
• Antibody chains must be labeled H and L for Heavy and Light, respectively.
• All other chains in the file will be interpreted to be the antigen.