What is DASH?
DASH is a database of structural alignments for all known structurally homologous protein domains and chains in the PDB.
The processing involves (a) clustering sequence-unique proteins from the PDB using CD-HIT at 99% sequence identity;
(b) decomposing the sequence representatives into domains using Protein Domain Parser (Alexandrov N, Shindyalov I; Bioinformatics 2003);
(c) aligning all domains against all domains on Google Cloud using RASH (Standley DM, Toh H, Nakamura H; BMC Bioinformatics 2007);
(d) building composite chain alignments from individual domain alignments.
(Rozewicki, et al.; Nucleic Acids Research 2019 [PubMed])
Last Update: 2019-09-19
Chain Alignments: 62,533,099
Domain Alignments: 104,731,068
Unsupported Chains: 51,078
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